Capella

Monthly Archives For: June 2011

June 29, 2011

ALN-VSP Data at 2011 ASCO Meeting

At the ASCO Annual Meeting in June 2011, we presented complete results from our Phase I clinical trial with ALN-VSP, a systemically delivered RNAi therapeutic for the treatment of patients with advanced solid tumors with liver involvement.

Read our press release ALN-VSP PhI ClinicalStudyResults-ASCO2011 (1.2MB PPT) ALN-VSP RNAi Roundtable, May 2011 (2.2 MB PPT) Listen to Dr. Jared Gollob discuss ALN-VSP data at ASCO 2011 (3.1MB MP3)

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June 22, 2011

Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery.

J.Shi, et al.,Angew Chem Int Ed Engl. 2011 Jul 25;50(31).Epub 2011 Jun 22.

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June 18, 2011

Synergistic Silencing: Combinations of Lipid-like Materials for Efficacious siRNA Delivery

 K.A. Whitehead et al., Mol Therapy. 2011 Jul 12. doi: 10.1038/mt2011.141. Epub 2011 Jun 18.

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June 18, 2011

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

J. Baughman et. al, Nature. 2011 Jun 19. doi: 10.1038/nature10234. Epub 2011 Jun 18.

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June 15, 2011

ALN-HTT HDSA Presentation

In June 2011, our scientists presented an update on our Huntington’s disease program, ALN-HTT, at the 26th Annual HDSA National Convention. 

HDSA 2011 Presentation (1.8MB PPT)

 

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June 8, 2011

MicroRNAs 103 and 107 regulate insulin sensitivity.

M. Trajkovski et. al, Nature. 2011 Jun 8;474(7353):649-53. doi: 10.1038/nature10112.

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June 6, 2011

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.

K. J. Rayner et. al, J Clin Invest. 2011 Jul 1;121(7):2921-31. doi: 10.1172/JCI57275. Epub 2011 Jun 6.

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