At the annual ASCO meeting in June 2012, we presented data from our ALN-VSP Phase I extension study. Overall, the results demonstrated disease control lasting more than six months in the majority of patients treated on the extension study, including a complete response (CR) in an endometrial cancer patient who had multiple liver metastases.View our poster (3.72 MB PDF) View our release
Results from the extension study also give us increased confidence in long-term chronic dosing with RNAi therapeutics delivered via LNPs, as patients have received drug twice a month for up to nearly two years, and approximately 11 months on average. In this study, chronic dosing of up to 23 months with ALN-VSP was found to be generally safe and well tolerated.
If you’re at ASCO, our poster can be viewed today in the Development Therapeutics-Experimental Therapeutics poster session from 8 AM-12 PM CDT.