Capella

Posts Tagged with: RNA-platform

February 9, 2012

Novel Method for Monitoring RNAi Activity in Blood Samples

Our scientists discovered a new method for monitoring RNAi activity in blood samples.  The results were presented at the Keystone Gene Silencing by small RNAs symposium (Vancouver, February 7-12).  This new method, circulating extracellular RNA detection (cERD), allows quantitative measurement of tissue-specific mRNA silencing from biological fluids including blood and cerebrospinal fluid (CSF).

View our  poster (1.18 MB PDF) Read our press release

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February 2, 2012

A Rapid Two-step Method for Isolation of Functional Primary Mouse Hepatocytes: Cell Characterization and Asialoglycoprotein Receptor Based Assay Development

Severgnini et al., Cytotechnology. 2011 Nov 22 (Epub)

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January 31, 2012

Comprehensive Evaluation of Canonical Versus Dicer-substrate siRNA in Vitro and in Vivo

D. Foster et al., RNA. 2012 Jan 31. (Epub)

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January 24, 2012

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

T. Novobrantseva et al., Mol Ther-Nucleic Acids. Epub 2012 Jan 24.

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September 24, 2009

Alnylam RNAi Roundtable: RNAi Lead Discovery

In September 2009, we hosted an RNAi Roundtable to provide a deep dive into our RNAi Lead Discovery, or RLD, efforts.

RLD RNAi Roundtable webcast, September 2009 (47.4 MB MP3) RLD RNAi Roundtable, September 2009 (2.1MB PPT)

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August 27, 2008

Novel therapeutic modalities to address nondrugable protein interaction targets.

E. B. DeSouza et. al, Neuropsychopharmacology. 2009 Jan;34(1):142-58. Epub 2008 Aug 27.

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December 1, 2005

Translating RNA interference into therapies for human disease.

N. Mahanthappa et. al, Pharmacogenomics. 2005 Dec;6(8):879-83.

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December 1, 2004

RNA interference and chemically modified small interfering RNAs.

M. Manoharan, Curr Opin Chem Biol. 2004 Dec;8(6):570-9.

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