Capella

We hosted a series of online "RNAi Roundtables" in August and September, at which Alnylam scientists, clinical collaborators, and patients or patient advocates reviewed recent progress in many of the company's late-stage pipeline programs and discussed the related disease areas.

We presented additional pre-clinical data further elucidating fitusiran’s novel mechanism of action at the International Society of Thrombosis and Haemostasis (ISTH) Congress, held July 8 – 13, 2017 in Berlin, Germany. Presentation on the development of a PK-PD model of fitusiran Presentation on measurement of thrombin generation...

We presented pre-clinical data with ALN-F12 at the International Society of Thrombosis and Haemostasis (ISTH) Congress, held July 8 – 13, 2017 in Berlin, Germany. Data showed that reduction of hepatic factor XII (FXII) expression in mice by ALN-F12 inhibits thrombosis without increasing bleeding risk. We believe that reduction of plasma FXII by ALN-F12 represents a promising approach for the prophylactic treatment of thrombosis. View the presentation

We reported new positive results from our ongoing Phase 2 open-label extension (OLE) study with fitusiran in patients with hemophilia A and B, with or without inhibitors, at the International Society of Thrombosis and Haemostasis (ISTH) Congress, held July 8 – 13, 2017 in Berlin, Germany. Read our press release View the complete Phase 2 OLE data presentation

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