There are four types of acute hepatic porphyrias (AHP): acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), and ALAD-deficient porphyria (ADP).
Acute hepatic porphyrias are characterized by acute, potentially life-threatening attacks and chronic debilitating symptoms that negatively impact patients’ quality of life.
Attacks are commonly characterized by severe abdominal pain, vomiting, nausea, rapid heart rate (tachycardia), and constipation. During an attack, a person may also experience muscle weakness or paralysis, seizures, low sodium levels (hyponatremia), and mental changes such as anxiety, confusion, or hallucinations in severe cases.
HCP and VP are classified as acute but can also have symptoms that affect the skin—specifically blistering skin lesions on sun-exposed areas. Skin symptoms can be present with or without attacks.
HCPs: Want more information about this disease to share with patients? Start Here
Download the Alnyam ActTM Brochures for the Acute Hepatic Porphyrias