.colored-four-cards.vertical-cards {
  max-width: 1010px;
  margin: auto;
}
.colored-four-cards.horizontal-cards {
  margin: auto;
  max-width: 1170px;
}

.colored-four-cards.vertical-cards
  .colored-card-container
  > .field--items
  > .field--item {
  background: #f3f8fb;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item:nth-child(1) {
  background: #e8f2f8;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item:nth-child(2) {
  background: #faeaf5;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item:nth-child(3) {
  background: #fbefd5;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item:nth-child(4) {
  background: #e8f2f8;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item {
  border-radius: 18px;
}
.horizontal-description {
  font-size: 17px;
  flex-direction: column;
  font-weight: 300;
  color: #333;
  font-stretch: normal;

  font-style: normal;

  line-height: 1.41;

  letter-spacing: normal;

  color: #333;
}
.vertical-description {
  margin-top: 32px;
  font-size: 20px;
  font-weight: 300;
  color: #000000d9;
  line-height: 1.6;
}
.colored-four-cards.horizontal-cards {
  padding-bottom: 32px;
  padding-top: 32px;
}
.horizontal-cards .colored-section-describtion {
  max-width: 970px;
  margin-top: 32px;

  margin-left: auto;
  margin-right: auto;
}
.vertical-description {
  max-width: 730px;
  margin-left: auto;
  margin-right: auto;
}
@media (min-width: 991px) {
  .colored-four-cards.vertical-cards .colored-card-container {
    display: flex;
    align-items: center;
  }
  
  .vertical-cards .colored-card-wrapper p {
    max-width: 300px;
  }
  .horizontal-description {
    margin-top: 48px;
    justify-content: space-between;
    flex-direction: row;
  }
  .horizontal-description .cards-desc {
    max-width: 670px;
  }
  .colored-cards-header {
    margin-bottom: 32px;
    text-align: center;
    margin-top: 0;
  }
  .vertical-cards .colored-card-wrapper {
    display: flex;
    align-items: center;
    flex-wrap: wrap;
    padding-top: 13px;
    padding-bottom: 13px;
  }
  .colored-four-cards.vertical-cards
    .colored-card-container
    > .field--items
    > .field--item {
    flex: 0 0 calc(50% - 15px);
    background: #f3f8fb;
  }
  .colored-four-cards.vertical-cards
    .colored-card-container
    > .field--items
    > .field--item:nth-child(1),
  .colored-four-cards.vertical-cards
    .colored-card-container
    > .field--items
    > .field--item:nth-child(2) {
    margin-bottom: 32px !important;
  }
  .colored-four-cards.horizontal-cards
    .colored-card-container
    > .field--items
    > .field--item {
    flex: 0 0 calc(25% - 22px);
    border-radius: 18px;
    height: 440px;
  }
  .colored-four-cards.horizontal-cards .colored-card-container p {
    padding: 32px;
  }
  .colored-four-cards.horizontal-cards {
    padding-top: 64px;
    padding-bottom: 64px;
  }
}

.horizontal-cards .image-field {
  max-width: 230px;
  margin-left: auto;
  margin-right: auto;
}
.colored-four-cards .colored-card-container > .field--items {
  display: flex;
  justify-content: space-between;
  flex-wrap: wrap;
}
.custom-video .image-quote.overlap .quote p.quote-text {
  position: relative;
  max-width: 100%;
  font-size: 35px;
  line-height: 40px;
  font-weight: 300;
}
.custom-video .image-quote.overlap .quote {
  top: 242px;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item::before {
  background-image: url("/sites/default/files/inline-images/arrow.svg") !important;
  content: "";
  width: 65px;
  height: 84px;
  display: inline-block;
  position: absolute;
  bottom: 93px;
  left: -46px;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item:nth-child(1)::before {
  display: none;
}
.colored-four-cards.horizontal-cards
  .colored-card-container
  > .field--items
  > .field--item {
  position: relative;
}
.primary-hyperoxaluria .accordion-body ul {
  padding-left: 12px;
}
@media (max-width: 767px) {
  .colored-four-cards.horizontal-cards .slick-track > div:first-child {
    margin-left: 0;
  }
  .third-image .quote span {
    bottom: -36px;
  }
  .whole-accordian-column-content h2 {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 8px;
  padding-bottom: 8px;
}
 .primary-hyperoxaluria .transparency-accordion .accordian-content .accordion-item h2 button.accordion-button.collapsed::after, .transparency-accordion .accordian-content .accordion-item h2 button.accordion-button::after {
  top: -11px;
}
  .whole-patient-comes-first-section.custom-video .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/skinner-mob.png") !important;
  }
  .whole-patient-comes-first-section.second-image .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/hannah-mob.png") !important;
  }
  .whole-patient-comes-first-section.third-image .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/nathan-mob.png") !important;
  }
  .center-cards-container h2 {
  text-align: left;
}
  .colored-four-cards.horizontal-cards .slick-track > .slick-current.slick-active:nth-child(3){
    margin-left:0;
  }
  .colored-four-cards.horizontal-cards .slick-track > div::before {
    background-image: url("/sites/default/files/inline-images/arrow.svg") !important;
    content: "";
    width: 65px;
    height: 84px;
    display: inline-block;
    position: absolute;
    bottom: 134px;
   left: 254px;
    z-index: 3;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:last-child {
    margin-right: 15px;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:last-child::before {
    display: none;
  }
  .colored-four-cards.horizontal-cards .slick-track {
    display: flex;
  }
  .horizontal-cards .colored-card-wrapper img {
    max-width: 188px;
    margin-left: auto;
    margin-right: auto;
  }
  .horizontal-description {
    padding-right: 1px;
  }
  .colored-four-cards.horizontal-cards .slick-arrow.slick-next {
    right: 32px;
  }
  .colored-four-cards.horizontal-cards
    .slick-track
    > div.slick-current.slick-active {
    margin-left: 11px;
  }
  .horizontal-cards .colored-section-describtion {
    margin-right: 32px;
  }
  .colored-four-cards.horizontal-cards .colored-card-wrapper {
    padding-top: 0;
  }
  .colored-four-cards.horizontal-cards .slick-track > div {
    position: relative;
    border-radius: 18px;
    margin-right: 15px;
    margin-left: 15px;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(1) {
    background: #e8f2f8;
    z-index:99;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(2) {
    background: #faeaf5;
    z-index:99;
  }
  .custom-video .image-quote.overlap .quote p.quote-text {
    font-size: 24px;
    line-height: 28px;
    padding-right: 42px !important;
  }
  /*  .colored-four-cards.horizontal-cards   .slick-list{
    margin-left:-15px;
   margin-right:-15px;
  } */
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(3) {
    background: #fbefd5;
    z-index:99;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(4) {
    background: #e8f2f8;
  }
  .colored-four-cards.horizontal-cards
    .colored-card-container
    > .field--items
    > .field--item {
    border-radius: 18px;
  }
  .colored-four-cards.horizontal-cards .colored-cards-header {
    margin-left: 0;
    margin-right: 0;
  }
  .colored-four-cards.horizontal-cards .colored-card-wrapper {
    padding-left: 32px;
    padding-right: 34px;
    text-align: left;
    min-height: 440px;
  }
  .colored-four-cards.horizontal-cards .colored-card-container p {
    padding-top: 32px;
  }
  .colored-four-cards.horizontal-cards {
    padding-bottom: 64px;
    padding-left: 32px;
    padding-right: 0;
  }
  .baby-blue-bg {
    padding-left: 32px;
    padding-right: 32px;
  }
  .primary-hyperoxaluria p.mob-mb-48.font-20:not(:last-child) {
  margin-bottom: 16px !important;
  }
  .icon-div {
    max-width: 95px;
  }
  .toggle-popup {
    max-width: 94px;
  }
  .body-image img {
    max-height: 357px;
  }
  .colored-four-cards .slick-arrow {
    top: unset;
    bottom: 4px;
    position: absolute;
    width: 42px;
    z-index: 9;
    height: 41px;
    background: url(/themes/custom/alnylam/images/next-arrow.svg) no-repeat;
  }
  .colored-four-cards .slick-arrow.slick-next {
    transform: none;
    right: 16px;
  }
  .colored-cards-header {
    margin-top: 0;
    margin-bottom: 32px;
  }
  .colored-four-cards .slick-prev {
    left: 16px;
    transform: rotate(-180deg);
  }
  .colored-four-cards .slick-prev::before,
  .colored-four-cards .slick-next::before {
    display: none !important;
  }
  .colored-four-cards.vertical-cards {
    margin-left: 16px;
    margin-right: 16px;
  }
  .colored-cards-header {
    margin-left: 16px;
    margin-right: 16px;
  }
  .colored-card-wrapper {
    padding: 32px 16px 0 16px;
    text-align: center;

    min-height: 376px;
  }
  .colored-card-wrapper img {
    max-width: 158px;
    margin-left: auto;
    margin-right: auto;
  }
  .vertical-cards .colored-card-wrapper {
    background: #f3f8fb;
    min-height: 376px;
  }

  .colored-four-cards .slick-dots li {
    width: 8px;
    margin: 0;
  }
  .colored-four-cards .slick-dots li button {
    font-size: 6px;
    line-height: 20px;
    position: absolute;
    top: unset;
    bottom: 0;
    left: 0;
    width: 1px;
    height: 30px;
    content: "";
    opacity: 1;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-dots li button {
    border: 0;
  }
  .colored-four-cards .slick-dots li.slick-active button::before {
    height: 48px;
    margin-top: 0;
    opacity: 1;
    width: 1px;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-dots li button::before {
    font-family: "slick";
    font-size: 6px;
    line-height: 20px;
    position: absolute;
    top: unset;
    bottom: 0;
    left: 0;
    width: 1px;
    height: 30px;
    content: "";
    opacity: 1;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-dots {
    bottom: 0px !important;
  }
  .colored-four-cards .slick-dotted.slick-slider {
    padding-bottom: 84px;
  }
  .custom-video .image-quote div.cboxElement {
    width: 56px;
    height: 56px;
    bottom: 38px;
  }
  .custom-video .image-quote.overlap .quote {
    top: 320px;
  }
  .primary-hyperoxaluria .accordian-content .accordion-item {
    padding-left: 16px;
    padding-right: 16px;
  }
  .hyperoxaluria-accordion .whole-accordian-column-content.description h2 {
    padding-left: 32px;
    padding-right: 32px;
  }
  .center-cards-section {
    margin-top: 126px;
    padding-left: 32px;
    padding-right: 32px;
  }
 
    .colored-four-cards.horizontal-cards .slick-track > div.slick-current.slick-active {
  z-index: 9999;
}
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(4){
    z-index:9 !important;
  }
  
}
@media (max-width: 991px) and (min-width: 768px) {
  .vertical-cards .colored-card-wrapper {
    background: #f3f8fb;
    padding: 32px 16px;
    text-align: center;
    min-height: 376px !important;
  }
  .vertical-cards .slick-slide img {
    display: block;
    max-width: 158px;
    margin-left: auto;
    margin-right: auto;
  }
  .colored-cards-header {
    margin-top: 0;
    margin-bottom: 32px;
    font-size: 35px;
    line-height: 40px;
    text-align: center;
  }

  .vertical-cards .slick-slide {
    margin: 0 12px;
  }

  /* the parent */
  .vertical-cards .slick-list {
    margin: 0 -12px;
  }
  .colored-four-cards.vertical-cards {
    margin-left: 32px;
    margin-right: 32px;
  }
  .colored-section-describtion {
    padding-top: 115px;
  }
  .colored-four-cards .slick-dots li {
    width: 8px;
    margin: 0;
  }
  .colored-four-cards .slick-dots li button {
    font-size: 6px;
    line-height: 20px;
    position: absolute;
    top: unset;
    bottom: 0;
    left: 0;
    width: 1px;
    height: 30px;
    content: "";
    opacity: 1;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-dots li button {
    border: 0;
  }
  .colored-four-cards .slick-dots li.slick-active button::before {
    height: 51px;
    margin-top: 0;
    opacity: 1;
    width: 1px;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-dots li button::before {
    font-family: "slick";
    font-size: 6px;
    line-height: 20px;
    position: absolute;
    top: unset;
    bottom: 0;
    left: 0;
    width: 1px;
    height: 33px;
    content: "";
    opacity: 1;
    border: 1px solid #003366;
  }
  .colored-four-cards .slick-arrow {
    top: unset;
    bottom: -94px;
    position: absolute;
    width: 42px;
    z-index: 9;
    height: 41px;
    background: url(/themes/custom/alnylam/images/next-arrow.svg) no-repeat;
  }
  .colored-four-cards .slick-arrow.slick-next {
    transform: none;
    right: 55px;
  }

  .colored-four-cards .slick-prev {
    left: 55px;
    transform: rotate(-180deg);
  }
  .colored-four-cards .slick-prev::before,
  .colored-four-cards .slick-next::before {
    display: none !important;
  }
  .vertical-description {
    margin-top: 0;
  }
  .colored-four-cards .colored-card-container > .field--items {
    display: flex;
    justify-content: space-between;
    flex-wrap: wrap;
    margin-bottom: 0 !important;
  }
  .colored-four-cards .slick-dots {
    position: absolute;
    bottom: -98px !important;
    display: block;
    width: 100%;
    padding: 0;
    margin: 0;
    list-style: none;
    text-align: center;
  }
  .colored-four-cards.horizontal-cards {
    padding-bottom: 64px;
    padding-top: 64px;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:last-child {
    margin-right: 15px;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:last-child::before {
    display: none;
  }
  .colored-four-cards.horizontal-cards .slick-track {
    display: flex;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(1) {
    background: #e8f2f8;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(2) {
    background: #faeaf5;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(3) {
    background: #fbefd5;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(4) {
    background: #e8f2f8;
  }
  .colored-four-cards.horizontal-cards
    .colored-card-container
    > .field--items
    > .field--item {
    border-radius: 18px;
  }
  .colored-four-cards.horizontal-cards .colored-card-wrapper {
    min-height: 440px;
    padding-left: 32px;
    padding-right: 32px;
  }
  .horizontal-cards .image-field {
    margin-bottom: 32px;
  }
  .colored-four-cards.horizontal-cards {
    padding-bottom: 64px;
    padding-left: 32px;
    padding-right: 0;
  }
  .colored-four-cards.horizontal-cards .slick-track > div {
    position: relative;
    border-radius: 18px;
    margin-right: 15px;
    margin-left: 15px;
  }
  .colored-four-cards.horizontal-cards .slick-track > .slick-active {
    margin-left: 0;
  }

  .colored-four-cards.horizontal-cards
    .slick-track
    > .slick-active
    + .slick-active {
    margin-left: 15px;
  }
  .colored-four-cards.horizontal-cards
    .slick-track
    > div:nth-child(2)
    + .slick-active {
    margin-left: 15px;
  }
  .colored-four-cards.horizontal-cards .slick-track > div:nth-child(1) {
margin-left: 0 !important;
  }
  .colored-four-cards.horizontal-cards .colored-card-wrapper {
    max-width: 270px;
  }
  .horizontal-description {
    padding-right: 32px;
  }
  .horizontal-description .button-more {
    width: auto !important;
    padding: 21px 38px !important;
    height: auto !important;
    font-size: 18px;
    font-weight: 600;
    font-stretch: normal;
    font-style: normal;
    line-height: 1.33;
  }
  .horizontal-description .colored-four-cards .slick-dots {
  position: absolute;
  bottom: -89px !important;
  }
   .colored-four-cards.horizontal-cards  .slick-arrow{
    bottom: -84px;
  }
    .primary-hyperoxaluria .description--component{
    padding-left:0;
    padding-right:0;
  }
.custom-video .image-quote.overlap {
  bottom: -64px;
  margin-top: -32px !important;
  margin-bottom: 128px;
}
 .custom-video  .image-quote div.cboxElement {
  width: 54px !important;
  height: 54px;
  bottom: 34px;
  left: 56px;
}
  .custom-video .image-quote.overlap .quote p.quote-text {
  font-size: 24px;
  font-weight: 300;
  font-stretch: normal;
  font-style: normal;
  line-height: 1.17;
  letter-spacing: normal;
  color: #fff;
  width: 309px;
  padding-right: 0;
}
  .custom-video .image-quote.overlap .quote {
  top: unset;
  bottom: 112px;
  left: 56px;
}
  .custom-video .image-quote.overlap .quote {
  top: unset;
  bottom: 132px;
  left: 56px;
}
  .center-cards-wrapper > div {
  display: flex;
  justify-content: space-between;
}
  .center-cards-wrapper {
  padding-left: 60px;
  padding-right: 60px;
}
  .center-cards-wrapper > div > .field--item {
  flex: 0 0 311px;
  margin-left: 0;
  margin-right: 0;
}
  .colored-four-cards.horizontal-cards .slick-track > div::before {
 background-image: url("/sites/default/files/inline-images/arrow.svg") !important;
content: "";
width: 65px;
height: 84px;
display: inline-block;
position: absolute;
bottom: 115px;
left: 262px;
z-index: 3;

}
.whole-patient-comes-first-section.custom-video .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/skinner-image-tab.png") !important;
  }
    .whole-patient-comes-first-section.second-image .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/hannah-tab.png") !important;
      
  }
   .whole-patient-comes-first-section.third-image .image-quote.overlap{
    background-image: url("/sites/default/files/inline-images/nathan-tab.png") !important;
      
  }
}
.primary-hyperoxaluria .vertical-cards .colored-card-wrapper img {
  max-width: 158px;
}
.custom-video .image-quote.overlap .quote {
  top: 216px;
}