section#block-signupforupdates {
  background: #fff;
  max-width: 1130px;
  margin: auto;
  padding: 64px 0px;
  margin-top: -40px;
  position: relative;
}
section#block-signupforupdates h1 {
  margin-top: 0px !important;
}
section#block-signupforupdates h1 {
  padding-bottom: 48px;
  border-bottom: 1px solid #999;
}
section#block-signupforupdates h4 {
  margin-top: 64px;
}
/* -------- patient ---------- */
fieldset#edit-patient--wrapper legend {
  display: none;
}
div#edit-markup-01 h4 {
  text-align: center;
  font-size: 35px;
  font-weight: 300;
  margin-bottom: 35px;
}
/* -------- patient ---------- */
fieldset#edit-patient--wrapper legend {
  display: none;
}
div#edit-markup-01 h4 {
  text-align: center;
  font-size: 35px;
  font-weight: 300;
  margin-bottom: 35px;
}
fieldset#edit-patient--wrapper {
  text-align: center;
}
div#edit-patient {
  width: 55%;
  margin: auto;
}
#edit-patient--wrapper #edit-patient .radio {
  display: inline-block;
  width: 281px;
  cursor: pointer;
  margin-right: 25px;
}
#edit-patient--wrapper #edit-patient .radio label {
  background: #fff !important;
  border: 3px solid #bbd9eb;
  padding: 15px 35px;
  font-size: 18px;
  font-weight: 600;
  color: #00245b;
  margin-top: 32px !important;
  height: 72px;
  display: inline-block;
  text-transform: uppercase;
  line-height: 35px;
  width: 100%;
  transition: 0.3s all;
}
div#edit-patient .form-radio {
  display: none;
}
#edit-patient--wrapper .fieldset-wrapper {
  margin-bottom: 57px;
}
#edit-patient--wrapper #edit-patient .radio label.active,
#edit-patient--wrapper #edit-patient .radio label:hover {
  background: #00254b !important;
  color: #fff !important;
  border: 3px solid #00254b;
}
div#edit-patient .radio .option {
  padding-left: 0;
}
/* ----------- personal information ------------ */
div#edit-personal-information .panel-heading {
  display: none;
}
div#edit-personal-information .panel-body {
  max-width: 880px;
  margin: auto;
  padding: 40px 0 35px 0;
}
#edit-markup-05 .intro_custom_subtitle {
  font-weight: 400;
  font-size: 20px;
  line-height: 30px;
  margin-bottom: -10px;
}
div#edit-personal-information {
  background-color: #f8f8f8;
  border: none;
  margin: 25px -100vw 0 -100vw;
}
#edit-personal-information .panel-body .form-item-country {
  display: inline-block;
  width: 48.5%;
}

#edit-personal-information .panel-body .form-item-zip-postal-code {
  width: 48.5%;
  float: right;
}

#edit-personal-information .panel-body .form-control {
  display: block;
  height: 45px;
  width: 100%;
  padding: 10px 10px 10px 10px;
  margin: 0;
  line-height: 30px;
  background: #ffffff;
  color: #000;
  font-weight: 400;
  border: none;
  border-radius: 0;
}

#edit-personal-information .panel-body .intro_custom_subtitle {
  font-size: 20px;
  line-height: 30px;
  font-style: italic;
  font-weight: 400;
  color: #333333;
}

#edit-personal-information .panel-body .control-label {
  font-weight: 600;
  margin-bottom: 5px;
  color: #7b7b7b;
  font-size: 17px;
  line-height: 24px;
}

#edit-personal-information .panel-body .form-group {
  margin-bottom: 25px;
}
#edit-personal-information .panel-body .form-item-i-describe-myself-as-a- {
  width: 48.5%;
}
#edit-personal-information .panel-body .form-item-medical-specialization {
  /* display: inline-block !important; */
  width: 48.5%;
}
#edit-personal-information .panel-body .form-item-professional-designation {
  float: right;
  width: 48.5%;
}
/* ------- im intrested in ------- */
#edit-interested .panel-heading {
  display: none;
}
div#edit-interested .panel-body {
  max-width: 880px;
  margin: auto;
  padding-left: 0;
  padding-right: 0;
}
div#edit-interested {
  border: none;
}

div#edit-markup-02 h4 {
  font-size: 35px;
  font-weight: 300;
  color: #003366;
  text-align: center;
  margin-top: 40px;
}

#edit-interested .panel-body div#edit-markup-06 {
  text-align: center;
  padding-bottom: 0;
}

div#edit-markup-06 .btn-primary {
	border-radius: 0px;
	margin: 35px 0 23px 0;
	background: #fff !important;
	border: 3px solid #bbd9eb;
	padding: 15px 35px;
	font-size: 18px;
	font-weight: 600;
	color: #00245b;
	height: 72px;
	display: inline-block;
	text-transform: uppercase;
	line-height: 35px;
	transition: .3s all;
}

div#edit-markup-06 .btn-primary:hover{
  background: #00254b !important;
  color: #fff;
  border: 3px solid #00254b;
}


div#edit-interested .panel-body #edit-markup-03 {
  padding-bottom: 10px;
}
div#edit-markup-03 .intro_custom_subtitle {
  font-size: 20px;
  line-height: 30px;
  color: #333333;
  font-weight: 400;
}
#edit-interested .panel-body .control-label {
  font-size: 15px;
  color: #7b7b7b;
}
#edit-interested .panel-body .checkbox {
  display: inline-block;
  width: 49%;
  margin-bottom: 10px;
}
#edit-interested .panel-body .checkbox label {
  margin-bottom: 20px;
  padding-left: 38px;
}
#edit-interested
  .panel-body
  .form-item-by-submitting-this-form-i-agree-to-the-alnylam-privacy-policy-i- {
  width: 100%;
  margin-top: 15px;
  border-top: 1px solid #999;
}
#edit-interested .panel-body .checkbox input[type="checkbox"] {
  width: 1.6em;
  height: 1.6em;
  position: absolute;
  left: 18px;
}
.webform-submission--us-residents-form .panel-default {
  border-color: transparent;
}
#edit-interested
  .panel-body
  .form-item-by-submitting-this-form-i-agree-to-the-alnylam-privacy-policy-i-
  label {
  margin-bottom: 20px;
  padding-left: 34px;
  margin-top: 45px;
}
#edit-interested
  .panel-body
  .form-item-by-submitting-this-form-i-agree-to-the-alnylam-privacy-policy-i-.js-form-item-by-submitting-this-form-i-agree-to-the-alnylam-privacy-policy-i-.checkbox
  .control-label:before {
  top: 45px !important;
}
div#edit-markup-04 .optional {
  text-align: left;
  font-style: italic;
  font-size: 17px;
  color: #7b7b7b;
  font-weight: 400;
}
div#edit-actions-01 {
  text-align: center;
  padding-bottom: 75px;
}
button#edit-actions-01-submit {
	margin: 20px auto;
	background: #fff !important;
	border: 3px solid #bbd9eb;
	padding: 15px 35px;
	font-size: 18px;
	font-weight: 600;
	color: #00245b;
	height: 72px;
	display: inline-block;
	text-transform: uppercase;
	line-height: 35px;
	transition: .3s all;
	width: 25%;
}
button#edit-actions-01-submit:hover {
 background: #00254b !important;
  color: #fff;
  border: 3px solid #00254b;
}

section#block-webform .panel {
  box-shadow: none;
}