Complement-Mediated Disease

We have presented pre-clinical data with ALN-CC5, an RNAi therapeutic for the treatment of complement-mediated diseases, at the 6th International Conference on Complement Therapeutics being held June 18 – 23, 2013. The data showed that administration of a GalNAc-siRNA conjugate targeting the C5 component of complement resulted in potent, dose-dependent, and durable silencing of C5 liver mRNA, knockdown of C5 serum protein levels, and inhibition of complement-mediated hemolytic activity in rodents. [spotlight-link icon="presentation" href="" type="(0.8 MB PDF)"] View our presentation [/spotlight-link] [spotlight-link icon="release" href="" type=" "] Read our press release[/spotlight-link]  


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