Amyloidosis Testing & Counseling

A family living with hATTR amyloidosis

 hattr amyloidosis

Alnylam Act TM: Third-Party Genetic Testing and Counseling Programs Offered at No Charge

Alnylam is sponsoring no-charge third-party genetic testing and counseling for individuals who may carry a gene mutation known to be associated with hereditary ATTR (hATTR) amyloidosis. The Alnylam ActTM program was created to reduce barriers to genetic testing and counseling to help people and their healthcare providers make more informed decisions about their health.


The genetic testing service is available in the United States and Canada and the genetic counseling service is available in the United States. Learn more about what genetic testing and counseling are and how the process works here or by downloading the brochures below.

About hATTR Amyloidosis

hATTR amyloidosis is an inherited, progressive disease caused by a genetic mutation that results in the buildup of misfolded transthyretin (TTR) protein. This results in the formation of amyloid deposits in the heart, nerves, and gastrointestinal tract. hATTR amyloidosis affects approximately 50,000 people worldwide. Treatment options for people with this disease are limited and many people remain undiagnosed or misdiagnosed.


Symptoms of hATTR amyloidosis vary from person to person, depending on which organs or tissues are affected. As the disease progresses, symptoms may worsen (eg, numbness or tingling of the feet can result in the need to walk with an aid or use a wheelchair) and can lead to significant disability, decreased quality of life, and, in many instances, a shortened lifespan.


HCPs: Want more information about this disease to share with patients? Start Here

Genetic testing and counseling may help to:
  • Identify risk of disease for patients and their family members
  • Shorten the time to diagnosis and prevent misdiagnoses
  • Determine if patients are eligible to participate in clinical trials
  • Provide information about support resources such as patient advocacy organizations


Download the Alnyam ActTM Brochures for hATTR Amyloidosis

For Healthcare Professionals

Download PDF >

For Patients

Download PDF >


RNA interference marks a revolution in biology built on Nobel Prize-winning research.

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The Bridge is a program designed to help raise awareness of hereditary ATTR (hATTR) amyloidosis and promote education on the condition for patients and their families.

Visit Site >


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