Patients can be diagnosed with PH1 at any age, but most individuals experience their first symptoms in early childhood.
For many patients, PH1 is not diagnosed immediately. Since kidney stones in adults are more commonplace, adult patients with PH1 often spend many years undiagnosed until they present with severe kidney disease.
As PH1 progresses, it often results in end-stage renal disease, a life-threatening condition that prevents the kidneys from filtering fluids and waste from the body effectively.
Consequently, the build-up of oxalate can lead to the deposition of oxalate crystals in the eyes, bones, skin, heart, and central nervous system, causing diminished vision, bone fractures, ulcers, heart failure, and other complications.