Media Kit

Media Inquiries

Christine Lindenboom

SVP, Investor Relations & Corporate Communications
media@alnylam.com

About Alnylam

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality and is now advancing a new class of innovative medicines to address the needs of patients who have limited or inadequate treatment options. Our pipeline is focused on 4 therapeutic areas: genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases.

Learn More About Alnylam ›

About Alnylam

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality and is now advancing a new class of innovative medicines to address the needs of patients who have limited or inadequate treatment options. Our pipeline is focused on 4 therapeutic areas: genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases.

Learn More About Alnylam ›

Resources


Corporate Backgrounder

A synopsis of our RNAi therapeutics, experience, and active pipeline.

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Corporate Fact Sheet

A brief overview of our mission, products, and pipeline.

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Corporate Presentation

Additional details on our programs, products, and disease focus areas.

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Corporate Responsibility Summary

Our first Corporate Responsibility Summary details our approach to corporate responsibility and current and planned efforts in our five key areas of focus.

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Patient Access Philosophy

Our Patient Access Philosophy is our commitment to making the therapies we develop available to those who may benefit from them.

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Patient Access Philosophy Report

The Patient Access Philosophy Report is our annual readout on our progress against the pillars of our Patient Access Philosophy.

Download 2020 Report › (Format: PDF)
Download 2019 Report › (Format: PDF)


Alnylam Assist®

An overview of our patient support program for U.S. residents.

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Corporate Logos

Our company logo in various sizes.

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Alnylam Rare Disease Trend Report

Our inaugural Rare Disease Trend Report is based on survey responses from >30 U.S. payer and plan decision-makers and provides a unique window into the minds of insurers about orphan drug access.

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Read Bios ›

Leadership Team

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John Maraganore, PhD

Chief Executive Officer

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Al Boyle, PhD

Chief Technical Operations and Quality Officer

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Pushkal Garg, MD

Chief Medical Officer

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Akshay Vaishnaw, MD, PhD

President, Research & Development

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Agnieszka Gallagher, JD

Chief Ethics and Compliance Officer

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Yvonne Greenstreet, MBChB

President & Chief Operating Officer

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Tolga Tanguler

Chief Commercial Officer

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Jeff Poulton

Chief Financial Officer

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Kelley Boucher

Chief Human Resource Officer

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John Maraganore, PhD

Chief Executive Officer

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Yvonne Greenstreet, MBChB, MBA

President & Chief Operating Officer

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Al Boyle, PhD

Chief Technical Operations and Quality Officer

Download My Photos ›

Tolga Tanguler

Chief Commercial Officer

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Pushkal Garg, MD

Chief Medical Officer

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Jeff Poulton

Chief Financial Officer

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Akshay Vaishnaw, MD, PhD

President, Research & Development

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Kelley Boucher

Chief Human Resource Officer

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Agnieszka Gallagher, JD

Chief Ethics and Compliance Officer

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The Science of RNAi

RNA interference (RNAi) is a breakthrough in understanding how genes are regulated in cells. It also represents a completely new approach to drug discovery and development.

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RNAi Therapeutics, A New Class of Medicine

How RNAi-Based Medicines Work

RNAi Therapeutic Process

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RNAi Fact Sheet

Learn about the history of RNAi and what it means for the advancement of human therapeutics.

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RNAi Activity Booklet for Kids

Learn about the basic science of RNAi through fun activities such word search, connect the dots, matching, and coloring. This activity booklet is intended for families and children aged 7-14.

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Disease Information

 

About Acute Hepatic Porphyria

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Acute hepatic porphyria (AHP) refers to a family of rare, genetic diseases characterized by potentially life-threatening attacks and, for some patients, chronic debilitating symptoms that negatively impact daily functioning and quality of life. AHP comprises 4 subtypes, each resulting from a genetic defect leading to deficiency in one of the enzymes of the heme biosynthesis pathway in the liver: acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and ALAD-deficiency porphyria.

 

About Hereditary ATTR Amyloidosis

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Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive and life-threatening disease that is caused by a mutation in the transthyretin (TTR) gene. TTR protein is produced primarily in the liver and is normally a carrier of vitamin A. The mutation results in the accumulation of amyloid deposits in multiple organs of the body, including the nerves, heart, and gastrointestinal tract. The condition can have a debilitating impact on a patient’s life and may lead to premature death within 4.7 years following diagnosis.

 

About Primary Hyperoxaluria Type 1

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Primary hyperoxaluria (PH) constitutes a group of rare inherited disorders of the liver characterized by the overproduction of oxalate, an end-product of metabolism. There are 3 types of PH: type 1 (PH1), type 2 (PH2), and type 3 (PH3). PH1 is the most common and severe form, accounting for 70% to 80% of all cases. PH1 affects approximately 4 individuals per million in the United States and Europe, with an estimated 1,300 to 2,100 diagnosed cases. In some regions, such as the Middle East and North Africa, the genetic prevalence of PH1 is higher.

 

About Hypertension

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Hypertension, also known as high blood pressure, is a complex multifactorial disease clinically defined by most major guidelines as a systolic blood pressure (SBP) of above 140 mm Hg or a diastolic blood pressure (DBP) greater than 90 mm Hg, though some guidelines have a lower threshold of a SBP above 130 mm Hg or a DBP greater than 80 mm Hg. More than one billion people worldwide live with hypertension, and fewer than 20 percent of those affected have it under control.

 

Products and Pipeline

Our pipeline of investigational RNAi therapeutics is focused on diseases with high unmet medical need that fall under 4 Strategic Therapeutic Areas (STArs): genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases. We have multiple programs in late-stage and early-stage clinical development.

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ONPATTRO® (patisiran)

Now available in the United States.

Download Fact Sheet › (Format: PDF)

GIVLAARI® (givosiran)

Now available in the United States.

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OXLUMO® (lumasiran)

Now available in the United States.

Download Fact Sheet › (Format: PDF)

Vutrisiran

Investigational therapeutic for the treatment of ATTR amyloidosis.

Download Fact Sheet › (Format: PDF)

Zilebesiran

Investigational therapeutic for the treatment of hypertension.

Download Fact Sheet › (Format: PDF)

See the Rest of Our Pipeline ›


Clinical Trials

Our clinical studies allow us to evaluate whether potential new treatments are safe and effective.

 

APOLLO-A and -B Phase 3 Studies

APOLLO-A evaluated the efficacy and safety of patisiran in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis) with polyneuropathy, and APOLLO-B is evaluating patisiran in patients with transthyretin amyloidosis with cardiomyopathy (ATTR amyloidosis).

Download Fact Sheet › (Format: PDF)

ENVISION Phase 3 Study

The ENVISION Phase 3 study evaluated the efficacy and safety of givosiran in patients with acute hepatic porphyria (AHP).

Download Fact Sheet › (Format: PDF)

ILLUMINATE-A, -B, and -C Phase 3 Studies

ILLUMINATE-A randomized, double-blind, placebo-controlled Phase 3 study evaluating safety and efficacy of lumasiran in children (age 6 or older) and adults with PH1. ILLUMINATE-B open-label, multicenter Phase 3 study evaluating safety and efficacy of lumasiran in infants and young children (under the age of 6) with PH1. ILLUMINATE-C open-label, multicenter Phase 3 study evaluating safety and efficacy of lumasiran in PH1 patients of all ages with advanced renal disease, including patients on dialysis.

Download Fact Sheet › (Format: PDF)

HELIOS-A and -B Phase 3 Studies

Evaluating the efficacy and safety of vutrisiran in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis) and with transthyretin amyloidosis cardiomyopathy (ATTR amyloidosis with cardiomyopathy).

Download Fact Sheet › (Format: PDF)

KARDIA-1 Phase 2 Study

Evaluating the efficacy and safety of zilebesiran as monotherapy across different doses administered quarterly and biannually in patients with mild-to-moderate hypertension.

Download Fact Sheet › (Format: PDF)

Click here to see all of our clinical studies.

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