Media Kit

Media Inquiries

Christine Lindenboom

SVP, Investor Relations & Corporate Communications
media@alnylam.com

About Alnylam

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality and is now advancing a new class of innovative medicines to address the needs of patients who have limited or inadequate treatment options. Our pipeline is focused on 4 therapeutic areas: genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases.

Learn More About Alnylam ›

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About Alnylam

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality and is now advancing a new class of innovative medicines to address the needs of patients who have limited or inadequate treatment options. Our pipeline is focused on 4 therapeutic areas: genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases.

Learn More About Alnylam ›

Resources


Corporate Fact Sheet

A brief overview of our mission, products, and pipeline.

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Corporate Presentation

Additional details on our programs, products, and disease focus areas.

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Patient Access Philosophy

Our commitment to making the therapies we develop available to those who will benefit from them.

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Alnylam Assist®

An overview of our patient support program for U.S. residents.

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Corporate Logos

Our company logo in various sizes.

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Leadership Team

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John Maraganore, PhD

Chief Executive Officer

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Yvonne Greenstreet, MBChB, MBA

Chief Operating Officer

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Pushkal Garg, MD

Chief Medical Officer

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Laurie Keating, JD

EVP, Chief Legal Officer and Secretary

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Kelley Boucher

Chief Human Resource Officer

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Barry Greene

President

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Saraswathy V. Nochur, PhD

SVP, Chief Regulatory Officer

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Jeff Poulton

Chief Financial Officer

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Akshay Vaishnaw, MD, PhD

President, Research & Development

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John Maraganore, PhD

Chief Executive Officer

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Barry Greene

President

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Yvonne Greenstreet, MBChB, MBA

Chief Operating Officer

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Saraswathy V. Nochur, PhD

SVP, Chief Regulatory Officer

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Pushkal Garg, MD

Chief Medical Officer

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Jeff Poulton

Chief Financial Officer

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Laurie Keating, JD

EVP, Chief Legal Officer and Secretary

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Akshay Vaishnaw, MD, PhD

President, Research & Development

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Kelley Boucher

Chief Human Resource Officer

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The Science of RNAi

RNA interference (RNAi) is a breakthrough in understanding how genes are regulated in cells. It also represents a completely new approach to drug discovery and development.

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RNAi Fact Sheet

Learn about the history of RNAi and what it means for the advancement of human therapeutics.

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Disease Information

 

About Acute Hepatic Porphyria

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Acute hepatic porphyria (AHP) refers to a family of rare, genetic diseases characterized by potentially life-threatening attacks and, for some patients, chronic debilitating symptoms that negatively impact daily functioning and quality of life. AHP comprises 4 subtypes, each resulting from a genetic defect leading to deficiency in one of the enzymes of the heme biosynthesis pathway in the liver: acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and ALAD-deficiency porphyria.

 

About Hereditary ATTR Amyloidosis

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Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive and life-threatening disease that is caused by a mutation in the transthyretin (TTR) gene. TTR protein is produced primarily in the liver and is normally a carrier of vitamin A. The mutation results in the accumulation of amyloid deposits in multiple organs of the body, including the nerves, heart, and gastrointestinal tract. The condition can have a debilitating impact on a patient’s life and may lead to premature death within 4.7 years following diagnosis.

 

About Primary Hyperoxaluria Type 1

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Primary hyperoxaluria (PH) constitutes a group of rare inherited disorders of the liver characterized by the overproduction of oxalate, an end-product of metabolism. There are 3 types of PH: type 1 (PH1), type 2 (PH2), and type 3 (PH3). PH1 is the most common and severe form, accounting for 70% to 80% of all cases. PH1 affects 1 to 3 individuals per million, with a higher prevalence in some regions, such as the Middle East and North Africa. In the United States and Europe, there may be approximately 2,500 to 5,000 cases.

 

Products and Pipeline

Our pipeline of investigational RNAi therapeutics is focused on diseases with high unmet medical need that fall under 4 Strategic Therapeutic Areas (STArs): genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS) & ocular diseases. We have multiple programs in late-stage and early-stage clinical development.

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ONPATTRO® (patisiran)

Now available in the United States.

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GIVLAARI® (givosiran)

Now available in the United States.

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Lumasiran

Our investigational therapeutic for the treatment of primary hyperoxaluria type 1 (PH1).

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Vutrisiran

Our investigational therapeutic for the treatment of ATTR amyloidosis.

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See the Rest of Our Pipeline ›


Clinical Trials

Our clinical studies allow us to evaluate whether potential new treatments are safe and effective.

 

APOLLO-A and APOLLO-B Phase 3 Study

APOLLO A evaluated the efficacy and safety of patisiran in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis) with polyneuropathy and APOLLO B is evaluating patisiran in patients with transthyretin amyloidosis with cardiomyopathy (ATTR amyloidosis).

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ILLUMINATE-A and -B Phase 3 Study

This study evaluated the safety and efficacy of Lumasiran in infants, children, and adults with PH1.

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HELIOS -A and -B Phase 3 Study

Evaluating the efficacy and safety of vutrisiran in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis) and with transthyretin amyloidosis cardiomyopathy (ATTR amyloidosis with cardiomyopathy).

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Click here to see all of our clinical studies.

Get in touch

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